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Yemeni civil aviation deputy chief Mohammed Abdul Qader says the majority of the passengers were from the Comoros.
Those on board included families with children. The plane crashed before landing in Moroni, on the main island of Grand Comore, early on Tuesday morning. Many passangers were returning from Paris.
Abdul Qader says bodies have been spotted off the archipelago and that a rescue and search effort was under way.
The Comoros is an archipelago of three main islands situated about 2,900 kilometres south of Yemen, between Africa's southeastern coast and Madagascar.
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